Glycometabolomics-related biomarkers for early diagnosis and prediction of diabetic retinopathy progress and application thereof
AssigneeJoint Shantou International Eye Center of Shantou University and the Chinese University of Hong Kong
InventorsMingzhi ZHANG, Xin WEN, Qingping LIU
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Abstract
Glycometabolomics-related biomarkers for early diagnosis and prediction of diabetic retinopathy and the application thereof are provided in the present disclosure, belonging to the field of biomarkers. In the present disclosure, tear fluid is used as a biological sample, which is analysed through non-invasive sampling to identify glycometabolomics-related biomarkers that are capable of being used to diagnose and predict the progression of diabetic retinopathy.
Claims2
Reagents or kits for the early diagnosis and prediction of diabetic retinopathy progress, wherein the reagents or the kits are prepared using glycometabolomics-related biomarkers, and wherein:
- glycometabolomics-related biomarkers include one of a lactate, and a combination of the lactate with at least one monosaccharide,
- the diabetic retinopathy comprises proliferative diabetic retinopathy and non-proliferative diabetic retinopathy,
- the reagents or kits are reagents or kits for detecting the glycometabolomics-related biomarkers in tear fluids and
- the glycometabolomics-related biomarkers in the tear fluids are detected based on Ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS).
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