Novel polymer-coated crosslinked alginate gel fiber

A polymer-coated crosslinked alginate gel fiber comprising:

• a core layer;
• and
• a cationic polymer layer,
• wherein the core layer comprises an antibody-producing cell or a bioactive substance-producing cell embedded in crosslinked alginate gel that is obtained by performing a crosslinking reaction using chemically modified alginic acid derivatives represented by Formula (I) and Formula (II), and
• the cationic polymer layer coats the core layer,
• wherein the polymer-coated crosslinked alginate gel fiber has a length within a range of 0.01 to 100 m, and
• wherein the chemically modified alginic acid derivative represented by Formula (I) is a chemically modified alginic acid derivative represented by Formula (I) below:
• in Formula (I), (ALG) represents alginic acid;
• —NHCO— represents an amide bond through an arbitrary carboxyl group of the alginic acid;
• Akn-L1-, wherein Akn represents a cyclic alkyne group;
• -L1- is a divalent linker that bonds to the cyclic alkyne group (Akn), is a group selected from the group consisting of partial structural formulae, wherein in each formula, the right side of the broken line is not included, shown in the following table:
• No.
• Akn—L1—
• ALK-1a
• x1a = 1-6
• ALK-1b
• x1b = 1-6 y1b = 1-6
• ALK-2
• x2 = 1-6 y2 = 0-6 z2 = 1-6
• ALK-3a
• x3a = 1-6 y3a = 0-6 z3a = 2-6
• ALK-3b
• x3b = 1-6 y3b = 0-6 z3b = 1-6
• ALK-4
• x4 = 1-6 y4 = 2-6
• ALK-5a
• x5a = 1-6 y5a = 2-6 z5a = 2-6
• ALK-5b
• x5b = 1-6 y5b = 1-6 z5b = 2-6
• TABLE 72-2
• No.
• Akn—L1—
• ALK-6
• x6 = 1-6 y6 = 1-6 z6 = 2-6
• ALK-7a
• x7a = 1-6 y7a = 2-6 z7a = 2-6 v7a = 1-6
• ALK-7b
• x7b = 1-6 y7b = 1-6 z7b = 2-6 v7b = 1-6
• and
• the chemically modified alginic acid derivative represented by Formula (II) is a chemically modified alginic acid derivative represented by Formula (II) below:
• in Formula (II), (ALG) represents alginic acid;
• —NHCO— represents an amide bond through an arbitrary carboxyl group of the alginic acid;
• -L2- represents a linker selected from the group consisting of partial structural formulae, wherein in each formula, the outsides of the broken lines at both ends are not included, shown in the following table:
• No.
• —L2—
• LN-1
• a1 = 2-6 b1 = 2-6
• LN-2
• a2 = 2-6 b2 = 1-6
• LN-3
• a3 = 1-6 b3 = 1-6
• LN-4
• a4 = 1-6 b4 = 2-6
• LN-5
• a5 = 1-6
• LN-6
• a6 = 2-6