Properdin binding protein and use thereof
AssigneeLinno Pharmaceuticals Inc.
InventorsZhaozhong HAN, Lingyu LI, Mengfan PENG, Haiyang LI, Jun LUO, Hongya PAN
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Abstract
The present disclosure provides an isolated antigen binding protein. The isolated antigen binding protein can specifically bind to properdin. The present disclosure also provides an anti-properdin antibody and a preparation method and an application thereof.
Claims29
An isolated antigen binding protein specifically binds to properdin, wherein said isolated antigen binding protein comprises CDR1, CDR2 and CDR3, said CDR1 comprises an amino acid sequence as set forth in SEQ ID NO:
- 54 (X1X2CMX5, in which X1 is H or S or T or Y, X2 is G or Y, and X5 is A or G), said CDR2 comprises an amino acid sequence as set forth in SEQ ID NO:
- 55, and said CDR3 comprises an amino acid sequence as set forth in any one of SEQ ID NO:
- 12, SEQ ID NO:
- 13, SEQ ID NO:
- 14, SEQ ID NO:
- 15, SEQ ID NO:
- 16, and SEQ ID NO:
- 17.
The isolated antigen binding protein of claim 9, wherein said second antigen binding domain is indirectly linked to the isolated antigen binding protein of claim 10 by a linker, wherein said linker is a poly-glycine linker, wherein said linker comprises an amino acid sequence as set forth in SEQ ID NO:
- 108:
- GGGGSGGGGSGGGGS.
The method of claim of 27, wherein said diseases are caused by properdin or alternative pathway.
Dependencies are inferred from the claim text.