Variant fc domains and uses thereof
AssigneeCidara Therapeutics, Inc.
InventorLeslie W. TARI
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Abstract
This disclosure relates to variant Fc domain monomers, fusion proteins, conjugates, compositions, and related methods for treating or preventing disease. In particular, the disclosure features variant Fc domain monomers which include mutations at positions 246, according to the Kabat Index numbering.
Claims74
A variant Fc domain monomer, wherein the variant Fc domain monomer comprises an amino acid substitution at position 246, wherein the amino acid at position 246 is not a lysine, and wherein numbering is according to the EU index as in Kabat.
The variant Fc domain monomer of any one of claims 1-37, the conjugate of any one of claims 38-41, or the fusion protein of claim 42, wherein the Fc domain monomer dimerizes to form an Fc domain.
Dependencies are inferred from the claim text.