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US 2024/0174712 A1Published application
Compositions and methods for purifying alpha-1 antitrypsin using peptide ligands
OwnerStefano Menegatti, Wenning Chuinventors
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Abstract
The present disclosure provides compositions and methods related to the purification and/or isolation of α-1 antitrypsin (AAT). In particular, the present disclosure provides novel peptide ligands capable of binding recombinantly produced α-1 antitrypsin to facilitate its isolation and/or purification from processing fluid streams for subsequent therapeutic use.
Claims27
A peptide ligand comprising at least 6 amino acids, wherein the peptide comprises:
- (i) at least one histidine residue, and/or at least one lysine residue;
- (ii) at least one asparagine residue, and/or at least one serine residue, and/or at least one glutamate residue;
- or
- (iii) at least one phenylalanine residue, and/or at least one tryptophan residue;
- and
- (iv) wherein the peptide ligand binds α-1 antitrypsin.
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Dependencies are inferred from the claim text.