8-(picolinamide) substituted coumarin compound, and preparation method therefor and use thereof

A preparation method for 8-(picolinamide)-substituted coumarin compound, the method comprising:

• mixing
• with DIPEA, and then mixing with 4-(2-oxo-2H-chromene-8-carboxamido)pyridine-2-sulfonyl chloride, and reacting to obtain, wherein ring A is independently selected from the group consisting of:
• phenyl, naphthyl and a 5-14-membered aromatic heterocyclic group;
• a reaction formula thereof is as follows:
• wherein:
• the phenyl, naphthyl and 5-14-membered aromatic heterocyclic group are unsubstituted or substituted with one to five Ra;
• each Ra is independently selected from the group consisting of:
• deuterium, halogen, hydroxyl, sulfhydryl, amino, cyano, nitro, azide, methanesulfonyl, isopropanesulfonyl, phenyl sulfonyl, aminosulfonyl, methanesulfonate, isopropanesulfonate, phenylsulfonate, trifluoromethyl, trifluoromethoxy, formylamino, C1-8 alkoxy, C1-8 alkylcarbonyl, C1-8 alkoxycarbonyl, C1-8 alkyl, C3-8 cycloalkyl and phenyl;
• and
• for the Ra, the C1-8 alkyl, C3-8 cycloalkyl and phenyl are unsubstituted or substituted by one to five Rb;
• each Rb is independently selected from the group consisting of:
• deuterium, halogen, hydroxyl, sulfhydryl, amino, cyano, nitro, azide, methanesulfonyl, isopropanesulfonyl, phenylsulfonyl, aminosulfonyl, methanesulfonate, isopropanesulfonate, phenylsulfonate, trifluoromethyl, trifluoromethoxy, formylamino and C1-8 alkylcarbonyl.