Back to results
US 2024/0174608 A1Published application
Compounds for brain imaging
AssigneeThe General Hospital Corporation
InventorsChangning Wang, Yulong Xu, Can Zhang, Rudolph E. Tanzi
Life of this patent
Estimating the term…
Abstract
The present application provides radiolabeled tetrahydrocarbazole compounds that can be used as positron emission tomography imaging probes. Pharmaceutical compositions and methods of using these compounds for diagnosis and monitoring treatment of neurodegenerative diseases (such as Alzheimer's disease) are also provided.
Claims23
A compound of Formula (I):
- or a pharmaceutically acceptable salt thereof, wherein:
- n is selected from 0, 1, and 2;
- R1 and R2 are each independently selected from halo, CN, C(═O)NH2, C1-3 alkyl, C1-3 haloalkyl, C1-3 alkoxy, and C1-3 haloalkoxy, and
- one of R1 and R2 comprises a radioisotope selected from 11C and 18F.
1 more element
2-3. (canceled)
22-24. (canceled)
26-28. (canceled)
Dependencies are inferred from the claim text.