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US 2024/0174596 A1Published application
(s)-3-amino-4,4-dihalocyclopent-1-enecarboxylic acid as selective inactivators of human ornithine aminotransferase
OwnerRichard B. Silverman, Sida Sheninventors
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Abstract
Disclosed are amino, fluoro-substituted cyclopentene carboxylic acid compounds. The disclosed compounds and compositions thereof may be utilized in methods for modulating human ornithine δ-aminotransferase (hOAT) activity, including methods for treating diseases or disorders associated with to hOAT activity or expression such as cell proliferative diseases and disorders.
Claims22
A compound of the following formula or a dissociated form, a non-protonated form, a zwitterion form, or a salt thereof:
- wherein a double bond is present between the a and & carbons or between the α and β carbons, and
- wherein each of R1 and R2 is independently selected from a halogen such as F, Cl, Br, and I.
-34. (canceled)
Dependencies are inferred from the claim text.