Induced extravasation by energy delivery to tissue

A system for treating a target tissue area of a patient comprising:

• an energy delivery device configured to deliver energy to the target tissue area and configured to deliver a plurality of molecules to the target tissue area;
• and
• a generator in electrical communication with the energy delivery device, wherein the generator includes at least one energy delivery algorithm configured to provide an electric signal of pulsed electric field energy deliverable to the at least one energy delivery body that induces extravasation within the target tissue area wherein the extravasation is sufficient to bias molecules delivered to the target tissue area toward entry to cells of the target tissue area.