Storage solutions for maintaining of axonal viability
AssigneeBoard of Regents, The University of Texas System
InventorsGeorge D. BITTNER, David M. JACKSON
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AssigneeBoard of Regents, The University of Texas System
InventorsGeorge D. BITTNER, David M. JACKSON
Estimating the term…
The disclosure relates to defined solutions for organ (heart, liver, kidney, etc,) vascular composite allografts or autografts (VCA: hand, limb, face, etc.) or tissue (peripheral nerves, spinal cord, skin) storage that preserve the electrophysiological functions of axons contained therein. The disclosure also concerns the use of isolated peripheral nerve segments and solid organs preserved in the defined solutions in autograft or allograft transplantation procedures, as well as the use of isolated peripheral nerve segments and solid organs preserved in the defined solutions in autograft/allograft transplantation procedures in combination with the peripheral nerve repair techniques of neurorrhaphy and axonal fusion primarily using polyethylene glycol known as PEG-fusion.
A nerve storage solution comprising calcium-free solution comprising sodium chloride, sodium acetate anhydrous, sodium gluconate, potassium chloride, and magnesium chloride and exhibiting no more than about 250-255 mOsm per liter (measured osmosality).
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A method of treating or storing an axon or tissue containing an axon comprising contacting said axon or tissue containing an axon with a nerve storage solution comprising calcium-free solution comprising sodium chloride, sodium acetate anhydrous, sodium gluconate, potassium chloride, and magnesium chloride and exhibiting no more than about 250-255 mOsm per liter (measured osmosality).
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Dependencies are inferred from the claim text.