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US 2024/0173427 A1Published application
Glypican 3 antibodies and conjugates thereof
AssigneeSeagen Inc.
InventorsTravis Biechele, William Arthur, Patrick Burke, Lori Westendorf
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Abstract
The invention provides murine, chimeric, and humanized antibodies that specifically bind to GPC3 and conjugates thereof.
Claims18
An anti-GPC3 antibody-drug conjugate compound having the formula
- in salt form, in particular in pharmaceutically salt form, or solvate thereof, or having the formula above in which the thio-substituted succinimide is in hydrolyzed form;
- wherein
- A is a Stretcher Unit;
- R2A is —C(═O)R2B wherein R2B is methyl, ethyl, propyl, iso-propyl, 2-methyl-prop-1-yl, 2,2-dimethyl-prop-1-yl, or vinyl, or R2A is methyl, ethyl, propyl, iso-propyl, prop-2-en-1-yl or 2-methyl-prop-2-en-1-yl;
- R7B is —H or —OH;
- Ab is an antibody as set forth in any of claims 1-16;
- S is a sulfur atom from the antibody;
- and
- subscript p is an integer from 1 to 4.
6 more elements
A pharmaceutical composition comprising a population of anti-GPC3 antibody-drug conjugate compounds having the formula:
- in salt form, in particular in pharmaceutically salt form, or solvate thereof, or having the formula above in which the thio-substituted succinimide is in hydrolyzed form;
- wherein
- A is a Stretcher Unit;
- R2A is —C(═O)R2B wherein R2B is methyl, ethyl, propyl, iso-propyl, 2-methyl-prop-1-yl, 2,2-dimethyl-prop-1-yl, or vinyl, or R2A is methyl, ethyl, propyl, iso-propyl, prop-2-en-1-yl or 2-methyl-prop-2-en-1-yl;
- R7B is —H or -OH;
- Ab is an antibody comprising the three heavy chain complementarity determining regions (CDRs) of SEQ ID NO:
- 1 and the three light chain CDRs of SEQ ID NO:2 wherein the CDRs are as defined by Kabat;
- S is a sulfur atom from the antibody;
- and
- subscript p is 2.
7 more elements
A pharmaceutical composition comprising a population of anti-GPC3 antibody-drug conjugate compounds having the formula:
- in salt form, in particular in pharmaceutically salt form, or solvate thereof, or having the formula above in which the thio-substituted succinimide is in hydrolyzed form;
- wherein Ab is an antibody comprising the three heavy chain complementarity determining regions (CDRs) of SEQ ID NO:1 and the three light chain CDRs of SEQ ID NO:2 wherein the CDRs are as defined by Kabat;
- S is a sulfur atom from the antibody;
- and
- subscript p is 2.
2 more elements
Dependencies are inferred from the claim text.