Human Papilloma Virus Vaccines and Uses of the Same for HPV Associated Diseases
OwnerDouglas E. BROUGH, Damodar R. ETTYREDDY +2inventors
InventorsDouglas E. BROUGH, Damodar R. ETTYREDDY, Qi YANG, Chen WANG
Life of this patent
Estimating the term…
Abstract
Provided herein are multi-antigenic human papilloma virus (HPV) molecular vaccine constructs for use and treatment of HPV associated disorders and pathologies; such as HPV molecular vaccines targeting HPV6 and HPV11 associated pathologies.
Claims23
A polynucleotide comprising a nucleic acid encoding the amino acid sequence of SEQ ID NO:
- 72.
2-7. (canceled)
9-10. (canceled)
A method of generating an HPV6 and HPV11 composition, vaccine or polynucleotide encoding a non-naturally occurring polypeptide for use in a composition or vaccine, the method comprising engineering HPV polynucleotide sequences to encode derivatives of naturally occurring HPV polypeptides, wherein at least one of the viral polypeptides has oncogenic biologic activity or an essential viral replication function, wherein a combination of one or more amino acid sequence substitutions, deletions, insertions, separations, or rearrangements are expressed via the composition, vaccine or encoded by the polynucleotide to generate derivative viral polypeptides, wherein HPV oncogenic biologic activity or essential HPV replication function is eliminated from the derivative viral polypeptides, but wherein host immune-responsiveness and/or immunogenic activity against the derivative viral polypeptides is retained or enhanced compared to the corresponding naturally occurring viral polypeptides.
14-19. (canceled)
Dependencies are inferred from the claim text.