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US 2024/0173354 A1Published application
Methods of inhibiting aging and treating aging-related disorders
AssigneeExostem Biotec Ltd.
InventorsChaya BRODIE, Aharon BRODIE
Life of this patent
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Abstract
Methods of treating an aging-associated disease, as well as inhibiting aging in a subject, by administering pharmaceutical compositions comprising unmodified and modified MSCs and their exosomes are provided.
Claims19
A method of inhibiting aging or treating an aging-associated disease in a subject, the method comprising administering to the subject a pharmaceutical composition substantially devoid of amniotic placenta mesenchymal stem cells (MSCs), and comprising a pharmaceutically acceptable carrier and at least one of:
- a. a chorionic placenta MSC;
- b. exosomes from a chorionic placenta MSC;
- c. a dedifferentiated MSC;
- d. exosomes from a dedifferentiated MSC;
- e. a differentiated MSC;
- f. exosomes from a differentiated MSC and
- g. a combination thereof;
- thereby inhibiting aging in a subject.
5 more elements
A genetically modified MSC, said MSC comprising any one of:
- (i) an exogenous microRNA let-7 and an RNA inhibitory molecule that binds to and inhibits miR-133b;
- (ii) at least one exogenous miR selected from miR-10b, miR-138, miR-145 and miR-675;
- (iii) at least one RNA inhibitory molecule that binds to and inhibits at least one of miR-424, miR-195, miR-16, miR-497, miR-135, miR-6793, miR-21 and miR-133b;
- (iv) at least one of exogenous miR-145, an RNA inhibitory molecule that binds to an inhibits miR-154 and a combination thereof;
- (v) at least one of exogenous miR-145, an RNA inhibitory molecule that binds to an inhibits miR-154 and a combination thereof;
- (vi) exogenous miR-375, exogenous lncRNA PLUTO, an RNA inhibitory molecule that binds to and inhibits miR-21 and a combination thereof;
- (vii) at least one of:
- exogenous lncRNA MEG3, exogenous miR-143 and a combination thereof;
- and
- (viii) MSC comprising exogenous miR-143, miR-10a, miR-373 and miR-1225.
7 more elements
Dependencies are inferred from the claim text.