New treatment

A method of treating moderate chronic obstructive pulmonary disease (COPD) in a human subject in need thereof, the method comprising administering to the human subject via inhalation two or more doses of a composition comprising a therapeutically effective amount of ensifentrine or a pharmaceutically acceptable salt thereof, wherein moderate COPD comprises a FEV1/FVC<0.7 and 50%≤FEV1<80% predicted FEV1 value, wherein FEV1 is forced expiratory volume in one second, and wherein FVC is forced vital capacity each as measured from 15 to 30 minutes following administration of a bronchodilator to the human subject, and wherein the method increases average FEV1 of the human subject by at least 90 mL 12 weeks following the administering to the human subject.