Pharmaceutical Combinations for Treating Cancer
OwnerSimon ITTIG, Christoph KASPER +4inventors
InventorsSimon ITTIG, Christoph KASPER, Falk SAUPE, Marlise AMSTUTZ, Mélodie DUVAL, Irene WAIZENEGGER
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Abstract
The present invention relates to a pharmaceutical combination comprising a recombinant Gram-negative bacterial strain and an immune checkpoint modulator (ICM) and their use in a method for the prevention, delay of progression or treatment of cancer in a subject.
Claims16
A pharmaceutical combination comprising:
- (a) a recombinant Gram-negative bacterial strain which comprises a polynucleotide molecule comprising a nucleotide sequence encoding a heterologous protein or a fragment thereof fused in frame to the 3′end of a nucleotide sequence encoding a delivery signal from a bacterial effector protein, wherein the nucleotide sequence encoding the delivery signal from a bacterial effector protein is operably linked to a promoter;
- (b) an immune checkpoint modulator (ICM), wherein the ICM is ezabenlimab;
- and optionally
- (c) one or more pharmaceutically acceptable diluents, excipients or carriers.
(canceled)
A kit of parts comprising a first container, a second container and a package insert, wherein the first container comprises at least one dose of a medicament comprising a recombinant Gram-negative bacterial strain which comprises a polynucleotide molecule comprising a nucleotide sequence encoding a heterologous protein or a fragment thereof fused in frame to the 3′end of a nucleotide sequence encoding a delivery signal from a bacterial effector protein, wherein the nucleotide sequence encoding the delivery signal from a bacterial effector protein is operably linked to a promoter, the second container comprises at least one dose of a medicament comprising an immune checkpoint inhibitor (ICM), wherein the ICM is ezabenlimab;
- and the package insert optionally comprises instructions for treating a subject for cancer using the medicaments.
Dependencies are inferred from the claim text.