Anticoagulant proteins and their use for treating diseases associated with the activation of neutrophils
AssigneeBioxodes
InventorsValérie PIREAUX, Stéphanie DEMOULIN, Edmond GODFROID, Joël TASSIGNON, Sandrine DEROCHETTE, Michel GUYAUX
Life of this patent
Estimating the term…
Abstract
Disclosed is an Ixodes ricinus salivary gland polypeptide and its use for inhibiting the extrinsic coagulation pathway and for treating and/or preventing diseases and conditions, such as thrombotic events, associated with the recruitment and activation of neutrophils following activation of the extrinsic coagulation pathway.
Claims14
A method of treating and/or preventing thromboinflammation in a subject in need thereof, comprising administering to said subject a therapeutically effective amount of a protein or polypeptide comprising a polypeptide that has at least 85% sequence identity with the amino acid sequence SEQ ID NO:
- 2.
A method of treating and/or preventing thromboinflammation in a subject in need thereof, comprising administering to said subject a therapeutically effective amount of a medicament comprising a protein or polypeptide comprising:
- a polypeptide that has at least 85% sequence identity with the amino acid sequence SEQ ID NO:
- 2, and
- at least one pharmaceutically acceptable excipient.
Dependencies are inferred from the claim text.