Loading patent…
AssigneeGlaxosmithkline Biologicals SA
InventorsChristiane Marie-Paule Simone Jeanne FERON, Stefan Jochen KEMMLER, Michael Thomas KOWARIK, Julien Laurent QUEBATTE
Estimating the term…
The present invention discloses a conjugate comprising an antigen (for example a saccharide antigen) covalently linked to a Pseudomonas aeruginosa PcrV carrier protein comprising an amino acid sequence which is at least 80% identical to the sequence of SEQ ID NO:1-4, wherein the antigen is linked (either directly or through a linker) to an amino acid residue of the P. aeruginosa PcrV carrier protein. The invention also discloses Pseudomonas aeruginosa PcrV proteins that contain glycosylation site consensus sequences.
A PcrV protein having an amino acid sequence that is at least 70% or 80% identical to the sequence of SEQ ID NO:1-4, said amino acid sequence comprising a D/E-X—N—X—S/T consensus sequence wherein X is any amino acid apart from proline.
Dependencies are inferred from the claim text.