Compounds and use thereof for treatment of neurodegenerative, degenerative and metabolic disorders

A compound having a structure of Formula (X),

• or a pharmaceutically acceptable salt thereof,
• wherein:
• Ring A is a substituted or unsubstituted heteroaryl,
• W is —CR′═ or —N═;
• L1 is a bond, substituted or unsubstituted alkylene, or substituted or unsubstituted heteroalkylene;
• L2 is —S(O)2—, or —C(O)—;
• R1 is hydrogen, —CX13, —CHX2, —CH2X1, —OCX13, —OCH2X1, —OCHX12, —CN, —OR1A, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl;
• R10 is independently halogen, —CX13, —CHX12, —CH2X1, —OCX13, —OCH2X1, —OCHX12, —CN, —OR1A, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl;
• p is an integer of 0 to 3;
• X1 is —F, —Br, —Cl, or —I;
• R1A is hydrogen, or substituted or unsubstituted alkyl;
• Each R2A and R2B is independently selected from hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, or substituted or unsubstituted heterocycloalkyl;
• or R2A and R2B together with the nitrogen atom form a substituted or unsubstituted heterocycloalkyl, or substituted or unsubstituted heteroaryl.