Novel benzotriazole derivative having inhibitory activity against ectonucleotide pyrophosphatase-phosphodiesterase, and use thereof

A compound selected from a compound represented by the following Formula 1, a tautomer thereof, a pharmaceutically acceptable salt thereof, a hydrate thereof, a solvate thereof and a stereoisomer thereof:

• wherein
• W1 is N or CRa;
• W2 is N or CRb;
• W3 is N or CRc;
• W4 is N or CRd;
• W5 is N or Cre;
• W6 is N or CRf;
• W7 is N or CRg;
• wherein Ra, Rb, Re, Rd, Re, Rf and Rg are each independently selected from the group consisting of hydrogen, halogen, cyano, nitro, alkyl, alkenyl, alkynyl, cycloalkyl, heterocyclyl, aryl and heteroaryl,
• R1, R2, R3 and R4 are each independently hydrogen, a hydroxyl group, a halogen group, —CF3, —(O)CF3, a C1-C13 alkyl group, a C1-C6 alkoxy group, an amino group (—NR7R8), a nitro group (—N(O)2), an amide group (—(C═O)NR7R8), a carboxylic group (—C(O)OH), a nitrile group (—CN), a C6-C10 aryl group, a C3-C10 cyclic group, a C3-C10 heteroaryl group, a C3-C10 heterocyclic group, or —C(O)—(C1-C13 alkyl);
• Z is present or absent, wherein when Z is present, Z is —O—, —CO—, —COO—, —CnHn+2—, O(CnHn+2)—, —(OC2H4)n—, —(C2H4O)n—, —(CnHn+2)O—, —(CnHn+2)CO—, —(CnHn+2)O(CmHm+2)—, —NR7(CnHn+2)—, —(NR7C2H4)n—, —(C2H4NR7)n—, or —(CnHn+2)NR7—;
• n is an integer from 0 to 8;
• R5 is -A-(R6)y,
• wherein A is a C3-C10 cyclic group, a C5-C10 bicyclic group, a C3-C10 heterocyclic group, a C6-C10 aryl group, or a C3-C10 heteroaryl group,
• R6 is hydrogen, a hydroxyl group, a halogen group, a C1-C13 alkyl group, a C1-C6 alkoxy group, a C1-C6 alkenyl group, a C6-C10 aryl group, a C3-C10 cyclic group, a C3-C10 heteroaryl group, a C3-C10 heterocyclic group, —C(O)—(C1-C13 alkyl), a tert-butyloxycarbonyl group (Boc), an amino group (—NR7R8), —(CmHm+2)NR7R8, a nitro group (—N(O)2), an amide group (—(C═O)NR7R8), an ester group (—(CmHm+2)C(O)OR7), a carboxylic group (—(C(O)OH), a nitrile group (—CN), a sulfonamide group (—(CmHm+2)NHS(O)2R7), a urea group, a sulfamoyl group (—(CmHm+2)NHS(O)2NHR7), a sulfonamide group, a sulfamoylalkyl group (—(CmHm+2)NHS(O)2NHR7), a sulfamoylalkyl group (—(CmHm+2)NR7S(O)2NHR8), a sulfide group (—(CmHm+2)SR7), a sulfone group (—(CmHm+2)S(O)2R7), or a phosphoryl group (—(CmHm+2)P(O)R7R8), or is bonded to the same carbon as carbon bonded to A to form a 3- to 10-membered saturated ring, is bonded to the same carbon as carbon bonded to A to form a 3- to 10-membered saturated heterocycle containing at least one heteroatom of N, O and S, is bonded to carbon adjacent to carbon bonded to A to form a 3- to 10-membered saturated ring, or is bonded to carbon adjacent to carbon bonded to A to form a 3- to 10-membered saturated heterocycle containing at least one heteroatom of N, O and S,
• m is an integer from 0 to 4, and
• y is an integer from 0 to 4,
• wherein the C1-C13 alkyl group, the C1-C6 alkoxy group, the C1-C6 alkenyl group, or the —C(O)—(C1-C13 alkyl) includes at least one substituent selected from the group consisting of hydrogen, a hydroxyl group, a halogen group, a C1-C13 alkyl group, a C1-C6 alkoxy group, an amino group (—NR7R8), a nitro group (—N(O)2), an amide group (—(C═O)NR7R8), a carboxylic group (—C(O)OH), a nitrile group (—CN), a urea group (—NR7(C═O)NR8—), a sulfonamide group (—NHS(O)2—), a sulfide group (—S—), a sulfonyl group (—S(O)2—), a phosphoryl group (—P(O)R7R8), a C6-C10 aryl group, a C3-C10 heteroaryl group, and a C3-C10 heterocyclic group,
• the C6-C10 aryl group, the C3-C10 heteroaryl group, C3-C10 cyclic group, the C3-C10 heterocyclic group or the C5-C10 bicyclic group includes at least one substituent selected from the group consisting of hydrogen, a hydroxyl group, a halogen group, a carbonyl group (—(C═O)R7R8), a C1-C3 alkyl group substituted or unsubstituted with halogen or a C3-C10 heterocyclic group, a C1-C3 alkoxy group substituted or unsubstituted with halogen or a C3-C10 heterocyclic group, C6-C10 phenoxy, an amino group (—NR7R8), a nitro group (—N(O)2), an amide group (—(C═O)NR7R8), a carboxylic group (—C(O)OH), a nitrile group (—CN), a urea group (—NR7(C═O)NR8—), a sulfonamide group (—NHS(O)2—), a sulfide group (—S—), a sulfonyl group (—S((O))2—), a phosphoryl group (—P(O)R7R8), a C6-C10 aryl group, a C3-C10 heteroaryl group and a C3-C10 heterocyclic group, and
• R7 and R8 are each independently hydrogen, a C1-C6 alkyl group, a C1-C6 alkenyl group, a C1-C6 alkynyl group, a C6-C10 aryl group, a C3-C10 heteroaryl group, a C3-C10 heterocyclic group, an amino group (—NH2), a nitro group (—N(O)2), -Boc, or —NHBoc, or R7, together with a nitrogen or carbon atom bonded to R8, forms a 3- to 7-membered saturated ring, which includes at least one of N, O, S, NH, C═N, C═O, —NHC(O)—, —NHC(O)NH—, —NHS(O)2—, or SO2, and is substituted with at least one of hydrogen, a C1-C13 alkyl group, a C6-C10 aryl group, a C3-C10 heteroaryl group, a hydroxyl group, a halide group or a cyano group,
• wherein the C3-C10 heteroaryl group and the C3-C10 heterocyclic group include at least one heteroatom selected from the group consisting of N, O, and S.