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US 2024/0116026 A1Published application
Vacuum driven gel filtration method
AssigneeWaters Technologies Corporation
InventorsDonna Osterman, Gabrielle Zabala, Matthew A. Lauber, Jennifer M. Nguyen, Anna Boardman
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Abstract
The present disclosure discusses a method of separating and/or purifying polynucleotides. The method includes injecting a sample into cartridge that is packed with a porous sorbent between opposing frits. Physical properties of the cartridge along with the use of hydrophilic fits allows efficient desalting of biopolymers using a vacuum to pull the sample through the cartridge.
Claims27
A desalting cartridge comprising:
- a body, wherein the body is substantially cylindrical and hollow, and wherein the body comprises a first end and a second end opposite the first end;
- an outlet coupled to the second end of the body;
- a first frit positioned in the body, wherein the first frit is composed of a first hydrophilic polymer, and wherein the first frit is positioned between the first end of the body and the second end of the body;
- a second frit positioned in the body, wherein the second frit is composed of a second hydrophilic polymer, and wherein the second frit is positioned between the first frit and the second end of the body;
- a sorbent bed disposed in the body between the first frit and the second frit;
- and
- a storage solution stored in the body between the first frit and the first end of the body.
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Dependencies are inferred from the claim text.