C-glycosyltransferase variants and use thereof
OwnerSang Yup LEE, Dongsoo YANG +1inventors
InventorsSang Yup LEE, Dongsoo YANG, Woo Dae JANG
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OwnerSang Yup LEE, Dongsoo YANG +1inventors
InventorsSang Yup LEE, Dongsoo YANG, Woo Dae JANG
Estimating the term…
The present invention relates to novel C-glycosyltransferase variants and a use thereof. The C-glycosyltransferase variants according to the present invention have improved glycosidic bond-forming ability as compared with wild-type C-glycosyltransferase, and thus can increase the glycoside production effects of polyketide groups and pseudo-natural products, particularly type I, II, III polyketide, nonribosomal peptides, phenylpropanoids, and other aromatic natural products, and thus can be useful for the preparation of a drug, a food additive, a nutritional supplement, and the like containing a C-glycoside compound as a constituent ingredient.
A C-glycosyltransferase variant comprising a mutation in at least one amino acid selected from the group consisting of F17, V93, V132, Y193, L164, and R322 in the C-glycosyltransferase amino acid sequence of SEQ ID NO:
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