Apyrase inhibitors
OwnerMatthew Duncton, Jeffrey D. Fowler +3inventors
InventorsMatthew Duncton, Jeffrey D. Fowler, John Clough, Tanya Sabharwal, Simon Hiebert
Life of this patent
Estimating the term…
Abstract
Disclosed herein are apyrase inhibitors of Formula (I) Also disclosed herein are methods for using the disclosed inhibitors, including in methods for protecting crops from pests. In one aspect the apyrase inhibitors are useful for enhancing the activity of pesticides for the protection of crops from pathogens and to support crop yield.
Claims41
A method for inhibiting apyrase, comprising contacting the apyrase with a compound of the formula
- wherein Ar1 is selected from aryl and heteroaryl;
- R1 is selected from hydrogen, C3-6 cycloalkyl, C1-6 alkyl, aralkyl, and C1-3 haloalkyl;
- R2 is selected from alkyl, aryl and heteroaryl;
- provided that the compound does not have the formula
A composition, comprising a compound of the formula
- wherein Ar1 is selected from aryl and heteroaryl;
- R1 is selected from hydrogen, C3-6 cycloalkyl, C1-6 alkyl, aralkyl, and C1-3 haloalkyl;
- R2 is selected from alkyl, aryl and heteroaryl;
- provided that the compound does not have the formula
- and
- a phytologically acceptable carrier.
A pesticidal composition, comprising
- a pesticide;
- a compound of the formula
- wherein Ar1 is selected from aryl and heteroaryl;
- R1 is selected from hydrogen, C3-6 cycloalkyl, C1-6 alkyl, aralkyl, and C1-3 haloalkyl;
- R2 is selected from alkyl, aryl and heteroaryl;
- provided that the compound does not have the formula
- and
- a phytologically acceptable carrier.
A fungicidal composition, comprising
- a fungicide;
- a compound of the formula
- wherein Ar1 is selected from aryl and heteroaryl;
- R1 is selected from hydrogen, C3-6 cycloalkyl, C1-6 alkyl, aralkyl, and C1-3 haloalkyl;
- R2 is selected from alkyl, aryl and heteroaryl;
- provided that the compound does not have the formula
- and
- a phytologically acceptable carrier.
Dependencies are inferred from the claim text.