4-hydroxybenzomorphans

A compound of formula:

• wherein
• A is chosen from —C(═O)NH2 and —C(═S)NH2;
• R2 and R2a are both hydrogen or taken together R2 and R2a are ═O;
• R3 is chosen from hydrogen, lower alkyl, alkenyl, aryl, heterocyclyl, benzyl and hydroxyalkyl;
• R4 is chosen from hydrogen, hydroxy, amino, lower alkoxy, C1-C20 alkyl and C1-C20 alkyl substituted with hydroxy or carbonyl;
• R11 is hydrogen;
• R12 is chosen from hydrogen, hydroxy, lower alkoxy and —NR13R14;
• or
• together, R11 and R12 form a carbonyl or a vinyl substituent;
• R13 and R14 are chosen independently from hydrogen and C1 to C7 hydrocarbon;
• and
• the dotted line represents an optional double bond.