Alpha-truxillic acid derivatives and pharmaceutical compositions thereof

A compound of having the structure:

• wherein
• one of R1 or R2 is —C(═O)OH and the other of R1 or R2 is —C(═O)OR13 or —C(═O)O-alkyl-R14,
• wherein
• R13 is cycloalkyl, unsubstituted or substituted aryl or heteroaryl, wherein the substituted aryl is substituted with halogen, heteroaryl, C2-C6 alkynyl —O (alkyl), amide, aryl or hydroxyaryl, and
• R14 is CF3, cycloalkyl, cycloheteroalkyl, aryl or heteroaryl;
• and
• R3, R4, R5, R6, R7, R8, R9, R10, R11 and R12 are each independently, H —OR15 or halogen
• wherein R15 is H, C1-10 alkyl, C2-10 alkenyl, C2-10 alkynyl, aryl, or heteroaryl,
• wherein when one of R1 or R2 is —C(═O)OH and R3, R4, R5, R6, R7, R8, R9, R10, R11 and R12 are each H, then the other of R1 or R2 is other than —C(═O)OR13 where R13 is tolyl, 1-naphthalene or 2-naphthalene or —C(═O)O-alkyl-R14 where the alkyl is a branched C2 alkyl and the R14 is phenyl, or an enantiomer or racemate thereof;
• or a pharmaceutically acceptable salt thereof.