Negative Pressure Therapy Devices, Systems, And Treatment Methods With Indwelling Urinary Catheters

A system for inducing negative pressure in a portion of a urinary tract, the system comprising:

• a negative pressure source;
• and
• a urinary catheter configured to be deployed in the urinary tract, comprising:
• (a) an inflow member comprising at least one inflow lumen in fluid communication with the negative pressure source, the inflow member comprising (i) a proximal portion, (ii) a retention portion configured to be deployed within a renal pelvis of the urinary tract, the retention portion comprising at least one drainage hole leading to the at least one inflow lumen, and (iii) at least one intermediate portion between the proximal portion and the retention portion, wherein the at least one intermediate portion is configured to extend through at least a portion of a kidney to the renal pelvis;
• and (b) an outflow member comprising at least one outflow lumen in fluid communication with the negative pressure source, the outflow member comprising (i) a proximal portion, (ii) a distal end configured to be positioned in a ureter or bladder, and (iii) at least one intermediate portion extending from the proximal portion to the distal end,
• wherein, when negative pressure is applied through the at least one inflow lumen by the negative pressure source, fluid is drawn into the at least one inflow lumen through the at least one drainage hole, and passes through the at least one inflow lumen and the at least one outflow lumen to the ureter and/or the bladder.

A method for deploying a negative pressure therapy system within a urinary tract, the method comprising:

• implanting a negative pressure source within a body outside of the urinary tract;
• inserting an inflow member of a urinary catheter through a kidney to a renal pelvis of the urinary tract, wherein the inflow member comprises at least one inflow lumen fluidly connected to the implanted negative pressure source, the inflow member further comprising (i) a proximal portion fluidly connected to the negative pressure source, (ii) a retention portion configured to be deployed within the renal pelvis, the retention portion comprising at least one drainage hole leading to the at least one inflow lumen, and (iii) at least one intermediate portion between the proximal portion and the retention portion;
• deploying the retention portion of the inflow member within the renal pelvis to maintain patency of fluid flow from the kidney through at least a portion of the at least one inflow lumen;
• and
• inserting an outflow member of the urinary catheter through the kidney, the renal pelvis, a ureter, and to a bladder of the urinary tract, wherein the outflow member comprises at least one outflow lumen configured to be in fluid communication with the negative pressure source, the outflow member further comprising (i) a proximal portion, (ii) a distal end configured to be positioned in the bladder, and (iii) at least one intermediate portion extending from the proximal portion to the distal end.