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US 2024/0083903 A1Published application
Aryl ether compounds as tead modulators
AssigneeMerck Sharp & Dohme Corp.
InventorsJongwon Lim, Vladimir Simov, Brandon A. Vara, Charles S. Yeung, Sebastian E. Schneider, Erin F. DiMauro
Life of this patent
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Abstract
The present invention is directed to a compound of Formula I: or a pharmaceutically acceptable salt thereof, as well as pharmaceutical compositions comprising them and methods of using such compounds or pharmaceutical salts thereof.
Claims19
A compound of Formula I:
- or a pharmaceutically acceptable salt thereof, wherein;
- Ring A is selected from a bicyclic ring structure:
- where the A′ ring may contain one or more heteroatoms selected from N, O or S atoms and the ring may be aromatic or aliphatic and the A″ ring may contain one or more heteroatoms selected from N, O or S atoms and the ring may be aromatic or aliphatic and at least one of A′ or A″ contains at least one heteroatom;
- Ring B is selected from phenyl, pyridinyl, 2,3-dihydro-1H-inden-5-yl or cyclohexyl;
- Ring D is selected from phenyl or pyridinyl;
- R is independently selected from H, C1-6alkyl or halo;
- R1 is selected from H, C3-C10 cycloalkyl, or C1-6alkyl, wherein said alkyl is optionally substituted with one to three groups selected from C1-6alkyl, C3-C10 cycloalkyl, CF3, or (CR2)zOR;
- R2is independently selected from OR, oxo, halo, —C1-6alkyl, NR2, CN, —C(O)OR, or C3-C10 cycloalkyl, where said alkyl is optionally substituted with one to three groups selected from —C1-6alkyl, C3-C10 cycloalkyl, —C(O)OR, OR or halo;
- R3 is independently selected from —C1-6alkyl, CF3, CHF2, halo, OR, OCF3, SCF3, SF5, or C(O)R, where said alkyl is optionally substituted with one to three groups from —C1-6 alkyl, OR, CF3, or halo;
- where when R3 is C4-C6 alkyl, it can cyclize with Ring B to form a bicyclic ring;
- n is selected from 0, 1, 2, 3 or 4;
- p is selected from 1, 2 or 3;
- and
- z is selected from 0, 1 or 2.
11 more elements
A compound selected from
- Ex. No.
- Name
- 1-1
- 3-(6,7-Dihydro-5H-pyrrolo[1,2-a]imidazol-2-yl)-N-methyl-4-(4-
- (trifluoromethyl)phenoxy)benzenesulfonamide
- 1-2
- 3-(5,6-Dihydro-4H-pyrrolo[1,2-b]pyrazol-2-yl)-N-methyl-4-(4-
- (trifluoromethyl)phenoxy)benzenesulfonamide
- 1-3
- 3-(5,6-Dihydro-8H-imidazo[2,1-c][1,4]oxazin-2-yl)-N-methyl-
- 4-(4-(trifluoromethyl)phenoxy)benzenesulfonamide
- 1-4
- N-Methyl-3-(8-methylimidazo[1,2-a]pyridin-3-yl)-4-(4-
- (trifluoromethyl)phenoxy)benzenesulfonamide
- 1-5
- 3-(5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl)-N-methyl-4-[4-
- (trifluoromethyl)phenoxy]benzene-1-sulfonamide
- 1-6
- 3-(6,7-dihydro-5H-pyrrolo[1,2-a]imidazol-3-yl)-N-methyl-4-[4-
- (trifluoromethyl)phenoxy]benzene-1-sulfonamide
- 1-7
- 3-(imidazo[1,5-a]pyrazin-3-yl)-N-methyl-4-[4-
- (trifluoromethyl)phenoxy]benzene-1-sulfonamide
- 1-8
- 3-(2H-indazol-3-yl)-N-methyl-4-[4-(trifluoromethyl)phenoxy]
- benzene-1-sulfonamide
- 1-9
- N-methyl-3-(5,6,7,8-tetrahydroimidazo[1,2-a]pyridin-2-yl)-4-[4-
- (trifluoromethyl)phenoxy]benzene-1-sulfonamide
- 1-10
- N-methyl-3-([1,2,4]triazolo[1,5-a]pyrimidin-2-yl)-4-[4-
- (trifluoromethyl)phenoxy]benzene-1-sulfonamide
- 1-11
- N-methyl-3-([1,3]thiazolo[5,4-b]pyridin-2-yl)-4-[4-
- (trifluoromethyl)phenoxy]benzene-1-sulfonamide
- 1-12
- 3-(5-methoxy-1H-benzimidazol-2-yl)-N-methyl-4-[4-
- (trifluoromethyl)phenoxy]benzene-1-sulfonamide
- 1-13
- 3-(1,2-benzothiazol-3-yl)-N-methyl-4-[4-
- (trifluoromethyl)phenoxy]benzene-1-sulfonamide
- 1-14
- 3-(5,6-dihydro-4H-pyrrolo[3,4-d][1,3]thiazol-2-yl)-N-methyl-
- 4-[4-(trifluoromethyl)phenoxy]benzene-1-sulfonamide
- 1-15
- N-methyl-3-([1,2,4]triazolo[1,5-a]pyrazin-2-yl)-4-[4-
- (trifluoromethyl)phenoxy]benzene-1-sulfonamide
- 1-16
- N-methyl-3-(4,5,6,7-tetrahydrothieno[3,2-c]pyridin-2-yl)-4-[4-
- (trifluoromethyl)phenoxy]benzene-1-sulfonamide
- 1-17
- 3-(3-cyano-5,6,7,8-tetrahydroimidazo[1,2-a]pyrazin-2-yl)-N-
- methyl-4-[4-(trifluoromethyl)phenoxy]benzene-1-sulfonamide
- 1-18
- 3-(imidazo[2,1-b][1,3]thiazol-6-yl)-N-methyl-4-[4-
- (trifluoromethyl)phenoxy]benzene-1-sulfonamide
- 1-19
- N-methyl-3-(pyrazolo[1,5-a]pyrimidin-2-yl)-4-[4-
- (trifluoromethyl)phenoxy]benzene-1-sulfonamide
- 1-20
- 3-(imidazo[1,2-a]pyridin-3-yl)-N-methyl-4-[4-
- (trifluoromethyl)phenoxy]benzene-1-sulfonamide
- 1-21
- 3-(8-aminoimidazo[1,2-a]pyridin-3-yl)-N-methyl-4-[4-
- (trifluoromethyl)phenoxy]benzene-1-sulfonamide
- 1-22
- N-methyl-3-(3-methyl-5,6-dihydro-8H-imidazo[5,1-c][1,4]
- oxazin-1-yl)-4-[4-(trifluoromethyl)phenoxy]benzene-1-
- sulfonamide
- 1-23
- 3-(6-chloroimidazo[1,2-b]pyridazin-3-yl)-N-methyl-4-[4-
- (trifluoromethyl)phenoxy]benzene-1-sulfonamide
- 1-24
- 3-(6-aminoimidazo[1,2-a]pyridin-3-yl)-N-methyl-4-[4-
- (trifluoromethyl)phenoxy]benzene-1-sulfonamide
- 1-25
- N-methyl-3-(7-methylimidazo[1,2-a]pyridin-3-yl)-4-[4-
- (trifluoromethyl)phenoxy]benzene-1-sulfonamide
- 1-26
- 3-(imidazo[1,2-a]pyrimidin-3-yl)-N-methyl-4-[4-
- (trifluoromethyl)phenoxy]benzene-1-sulfonamide
- 1-27
- 3-(imidazo[1,2-a]pyridin-2-yl)-N-methyl-4-[4-
- (trifluoromethyl)phenoxy]benzene-1-sulfonamide
- 1-28
- 3-(1,3-benzothiazol-2-yl)-N-methyl-4-[4-
- (trifluoromethyl)phenoxy]benzene-1-sulfonamide
- 1-29
- 3-(1,3-benzoxazol-2-yl)-N-methyl-4-[4-
- (trifluoromethyl)phenoxy]benzene-1-sulfonamide
- 1-30
- Methyl-2-{5-(methylsulfamoyl)-2-[4-
- (trifluoromethyl)phenoxy]phenyl}imidazo[1,2-a]pyridine-7-
- carboxylate
- 1-31
- N-methyl-3-(7-methylimidazo[1,2-a]pyridin-2-yl)-4-[4-
- (trifluoromethyl)phenoxy]benzene-1-sulfonamide
- 1-32
- 3-(7-fluoroimidazo[1,2-a]pyridin-2-yl)-N-methyl-4-[4-
- (trifluoromethyl)phenoxy]benzene-1-sulfonamide
- 1-33
- N-methyl-3-(8-methylimidazo[1,2-a]pyridin-2-yl)-4-[4-
- (trifluoromethyl)phenoxy]benzene-1-sulfonamide
- 1-34
- N-methyl-3-(6-methylimidazo[1,2-a]pyridin-2-yl)-4-[4-
- (trifluoromethyl)phenoxy]benzene-1-sulfonamide
- 1-35
- N-methyl-3-(pyrazolo[1,5-a]pyridin-2-yl)-4-[4-
- (trifluoromethyl)phenoxy]benzene-1-sulfonamide
- 1-36
- N-methyl-3-(4,5,6,7-tetrahydropyrazolo[1,5-a]pyridin-2-yl)-4-[4-
- (trifluoromethyl)phenoxy]benzene-1-sulfonamide
- 1-37
- N-methyl-3-(5,6,7,8-tetrahydroimidazo[1,5-a]pyridin-1-yl)-4-[4-
- (trifluoromethyl)phenoxy]benzene-1-sulfonamide
- 1-38
- (R)- or (S)-N-methyl-3-(2-methyl-2,3-dihydroimidazo[2,1-b][1,3]
- oxazol-6-yl)-4-[4-(trifluoromethyl)phenoxy]benzene-1-
- sulfonamide
- 1-39
- (S)- or (R)-N-methyl-3-(2-methyl-2,3-dihydroimidazo[2,1-b][1,3]
- oxazol-6-yl)-4-[4-(trifluoromethyl)phenoxy]benzene-1-
- sulfonamide
- 1-40
- 4-[4-(difluoromethyl)phenoxy]-3-(6,7-dihydro-5H-pyrrolo[1,2-
- a]imidazol-2-yl)-N-methylbenzene-1-sulfonamide
- 1-41
- (R)- or (S)-N-methyl-3-(6-methyl-6,7-dihydro-5H-pyrrolo[1,2-
- a]imidazol-2-yl)-4-[4-(trifluoromethyl)phenoxy]benzene-1-
- sulfonamide
- 1-42
- (S)- or (R)-N-methyl-3-(6-methyl-6,7-dihydro-5H-pyrrolo[1,2-
- a]imidazol-2-yl)-4-[4-(trifluoromethyl)phenoxy]benzene-1-
- sulfonamide
- 1-43
- (R)- or (S)-N-methyl-3-(7-methyl-6,7-dihydro-5H-pyrrolo[1,2-
- a]imidazol-2-yl)-4-[4-(trifluoromethyl)phenoxy]benzene-1-
- sulfonamide
- 1-44
- (S)- or (R)-N-methyl-3-(7-methyl-6,7-dihydro-5H-pyrrolo[1,2-
- a]imidazol-2-yl)-4-[4-(trifluoromethyl)phenoxy]benzene-1-
- sulfonamide
- 1-45
- 3-(2,3-dihydro-1H-imidazo[1,2-b]pyrazol-6-yl)-N-methyl-4-[4-
- (trifluoromethyl)phenoxy]benzene-1-sulfonamide
- 1-46
- 3-(2,3-dihydropyrazolo[5,1-b]oxazol-7-yl)-4-(4-fluorophenoxy)-
- N-methylbenzenesulfonamide
- 1-47
- 4-(4-chlorophenoxy)-3-(2,3-dihydropyrazolo[5,1-b]oxazol-7-yl)-
- N-methylbenzenesulfonamide
- 1-48
- 4-(3,4-difluorophenoxy)-3-(2,3-dihydropyrazolo[5,1-b]oxazol-
- 7-yl)-N-methylbenzenesulfonamide
- 1-49
- 3-(2,3-dihydropyrazolo[5,1-b]oxazol-7-yl)-N-methyl-4-(3-
- (trifluoromethyl)phenoxy)benzenesulfonamide
- 1-50
- 4-(4-acetylphenoxy)-3-(6,7-dihydro-5H-pyrrolo[1,2-a]imidazol-
- 2-yl)-N-methylbenzene-1-sulfonamide
- 2-1
- 3-(2,3-Dihydropyrazolo[5,1-b]oxazol-7-yl)-N-methyl-4-(4-
- (trifluoromethyl)phenoxy)benzenesulfonamide
- 2-2
- 3-(3-Methoxycinnolin-7-yl)-N-methyl-4-[4-
- (trifluoromethyl)phenoxy]benzene-1-sulfonamide
- 2-3
- 3-[4-methoxy-2-(trifluoromethyl)-1H-benzimidazol-7-yl]-N-
- methyl-4-[4-(trifluoromethyl)phenoxy]benzene-1-sulfonamide
- 2-4
- N-methyl-3-(2-oxo-2,3-dihydro-1H-indol-5-yl)-4-[4-
- (trifluoromethyl)phenoxy]benzene-1-sulfonamide
- 2-5
- N-methyl-3-(2-oxo-2,3-dihydro-1H-benzimidazol-5-yl)-4-[4-
- (trifluoromethyl)phenoxy]benzene-1-sulfonamide
- 2-6
- 3-(1,3-benzothiazol-5-yl)-N-methyl-4-[4-
- (trifluoromethyl)phenoxy]benzene-1-sulfonamide
- 2-7
- 3-(1H-indol-7-yl)-N-methyl-4-[4-(trifluoromethyl)phenoxy]
- benzene-1-sulfonamide
- 2-8
- 3-(1,3-dimethyl-2-oxo-2,3-dihydro-1H-benzimidazol-5-yl)-N-
- methyl-4-[4-(trifluoromethyl)phenoxy]benzene-1-sulfonamide
- 2-9
- N-methyl-3-(1H-pyrrolo[2,3-b]pyridin-4-yl)-4-[4-
- (trifluoromethyl)phenoxy]benzene-1-sulfonamide
- 2-10
- N-methyl-3-(1H-pyrrolo[2,3-b]pyridin-5-yl)-4-[4-
- (trifluoromethyl)phenoxy]benzene-1-sulfonamide
- 2-11
- 3-[2-(cyclopropylmethyl)-3-oxo-2,3-dihydro-1H-isoindol-5-yl]-
- N-methyl-4-[4-(trifluoromethyl)phenoxy]benzene-1-sulfonamide
- 2-12
- 3-(1-cyclopropyl-1H-benzimidazol-6-yl)-N-methyl-4-[4-
- (trifluoromethyl)phenoxy]benzene-1-sulfonamide
- 2-13
- 3-(2-amino-1H-benzimidazol-7-yl)-N-methyl-4-[4-
- (trifluoromethyl)phenoxy]benzene-1-sulfonamide
- 2-14
- 3-(2H-1,3-benzodioxol-5-yl)-N-methyl-4-[4-
- (trifluoromethyl)phenoxy]benzene-1-sulfonamide
- 2-15
- N-methyl-3-(1-methyl-1H-indazol-5-yl)-4-[4-
- (trifluoromethyl)phenoxy]benzene-1-sulfonamide
- 2-16
- N-methyl-3-(4,5,6,7-tetrahydropyrazolo[1,5-a]pyridin-3-yl)-4-[4-
- (trifluoromethyl)phenoxy]benzene-1-sulfonamide
- 2-17
- N-methyl-3-(6-methyl-6,7-dihydro-5H-pyrazolo[5,1-b][1,3]
- oxazin-3-yl)-4-[4-(trifluoromethyl)phenoxy]benzene-1-
- sulfonamide
- 2-18
- N-methyl-3-(4-methyl-3,4-dihydro-2H-pyrido[3,2-b][1,4]oxazin-
- 7-yl)-4-[4-(trifluoromethyl)phenoxy]benzene-1-sulfonamide
- 2-19
- 3-(isoquinolin-4-yl)-N-methyl-4-[4-(trifluoromethyl)phenoxy]
- benzene-1-sulfonamide
- 2-20
- 3-(isoquinolin-5-yl)-N-methyl-4-[4-(trifluoromethyl)phenoxy]
- benzene-1-sulfonamide
- 2-21
- 3-(7-methoxy-2-methylquinolin-6-yl)-N-methyl-4-[4-
- (trifluoromethyl)phenoxy]benzene-1-sulfonamide
- 2-22
- N-methyl-3-(3-oxo-3,4-dihydro-2H-1,4-benzoxazin-6-yl)-4-[4-
- (trifluoromethyl)phenoxy]benzene-1-sulfonamide
- 2-23
- 3-(7-fluoro-1-methyl-2-oxo-1,2,3,4-tetrahydroquinolin-6-yl)-N-
- methyl-4-[4-(trifluoromethyl)phenoxy]benzene-1-sulfonamide
- 2-24
- N-methyl-3-(quinolin-7-yl)-4-[4-(trifluoromethyl)phenoxy]
- benzene-1-sulfonamide
- 2-25
- N-methyl-3-[2-(methylamino)quinazolin-6-yl]-4-[4-
- (trifluoromethyl)phenoxy]benzene-1-sulfonamide
- 2-26
- N-methyl-3-(3-oxo-3,4-dihydro-2H-1,4-benzoxazin-8-yl)-4-[4-
- (trifluoromethyl)phenoxy]benzene-1-sulfonamide
- 2-27
- N-methyl-3-(quinoxalin-6-yl)-4-[4-(trifluoromethyl)phenoxy]
- benzene-1-sulfonamide
- 2-28
- N-methyl-3-(3-oxo-3,4-dihydro-2H-1,4-benzoxazin-7-yl)-4-[4-
- (trifluoromethyl)phenoxy]benzene-1-sulfonamide
- 2-29
- 3-(2-methoxyquinolin-6-yl)-N-methyl-4-[4-
- (trifluoromethyl)phenoxy]benzene-1-sulfonamide
- 2-30
- N-methyl-3-(1,5-naphthyridin-3-yl)-4-[4-
- (trifluoromethyl)phenoxy]benzene-1-sulfonamide
- 2-31
- N-methyl-3-(2-methylquinolin-6-yl)-4-[4-
- (trifluoromethyl)phenoxy]benzene-1-sulfonamide
- 2-32
- N-methyl-3-(4-oxo-1,4-dihydroquinazolin-7-yl)-4-[4-
- (trifluoromethyl)phenoxy]benzene-1-sulfonamide
- 2-33
- 4-[4-(difluoromethyl)phenoxy]-3-(2,3-dihydropyrazolo[5,1-
- b][1,3]oxazol-7-yl)-N-methylbenzene-1-sulfonamide
- 3-1
- 3-(5,6-Dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl)-N-methyl-4-(4-
- ((trifluoromethyl)thio)phenoxy)benzenesulfonamide
- 3-2
- 4-[3,5-bis(trifluoromethyl)phenoxy]-3-(5,6-dihydro-4H-pyrrolo
- [1,2-b]pyrazol-3-yl)-N-methylbenzene-1-sulfonamide
- 3-3
- 3-(5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl)-4-[3-fluoro-5-
- (trifluoromethyl)phenoxy]-N-methylbenzene-1-sulfonamide
- 3-4
- 3-(5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl)-N-methyl-4-[4-
- (trifluoromethoxy)phenoxy]benzene-1-sulfonamide
- 3-5
- 3-(5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl)-N-methyl-4-[3-
- (trifluoromethoxy)phenoxy]benzene-1-sulfonamide
- 3-6
- 3-(5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl)-N-methyl-4-[4-
- (2,2,2-trifluoroethyl)phenoxy]benzene-1-sulfonamide
- 4-1
- 3-(6,7-Dihydro-5H-pyrrolo[1,2-a]imidazol-2-yl)-N-methyl-4-
- (((1r,4r)-4-(trifluoromethyl)cyclohexyl)oxy)benzenesulfonamide
- 4-2
- 3-(6,7-dihydro-5H-pyrrolo[1,2-a]imidazol-2-yl)-N-methyl-4-((6-
- (trifluoromethyl)pyridin-3-yl)oxy)benzenesulfonamide
- 4-3
- 4-(4-tert-butylphenoxy)-3-(6,7-dihydro-5H-pyrrolo[1,2-a]
- imidazol-2-yl)-N-methylbenzene-1-sulfonamide
- 4-4
- 4-[(2,3-dihydro-1H-inden-5-yl)oxy]-3-(6,7-dihydro-5H-pyrrolo
- [1,2-a]imidazol-2-yl)-N-methylbenzene-1-sulfonamide
- 4-5
- 4-(3-chlorophenoxy)-3-(6,7-dihydro-5H-pyrrolo[1,2-a]imidazol-
- 2-yl)-N-methylbenzene-1-sulfonamide
- 4-6
- 3-(6,7-dihydro-5H-pyrrolo[1,2-a]imidazol-2-yl)-4-(3-
- fluorophenoxy)-N-methylbenzene-1-sulfonamide
- 4-7
- 3-(6,7-dihydro-5H-pyrrolo[1,2-a]imidazol-2-yl)-N-methyl-4-(4-
- methylphenoxy)benzene-1-sulfonamide
- 4-8
- 3-(6,7-dihydro-5H-pyrrolo[1,2-a]imidazol-2-yl)-N-methyl-4-[4-
- (propan-2-yl)phenoxy]benzene-1-sulfonamide
- 4-9
- 3-(6,7-dihydro-5H-pyrrolo[1,2-a]imidazol-2-yl)-4-(4-
- ethylphenoxy)-N-methylbenzene-1-sulfonamide
- 4-10
- 3-(6,7-dihydro-5H-pyrrolo[1,2-a]imidazol-2-yl)-4-(3-
- ethylphenoxy)-N-methylbenzene-1-sulfonamide
- 4-11
- 4-(3,4-difluorophenoxy)-3-(6,7-dihydro-5H-pyrrolo[1,2-a]
- imidazol-2-yl)-N-methylbenzene-1-sulfonamide
- 4-12
- 4-(4-chlorophenoxy)-3-(6,7-dihydro-5H-pyrrolo[1,2-a]imidazol-
- 2-yl)-N-methylbenzene-1-sulfonamide
- 4-13
- 3-(6,7-dihydro-5H-pyrrolo[1,2-a]imidazol-2-yl)-4-(4-
- fluorophenoxy)-N-methylbenzene-1-sulfonamide
- 4-14
- 3-(6,7-dihydro-5H-pyrrolo[1,2-a]imidazol-2-yl)-4-(4-
- methoxyphenoxy)-N-methylbenzene-1-sulfonamide
- 4-15
- 3-(6,7-dihydro-5H-pyrrolo[1,2-a]imidazol-2-yl)-N-methyl-4-
- [3-(trifluoromethyl)phenoxy]benzene-1-sulfonamide
- 4-16
- 4-[4-chloro-3-(trifluoromethyl)phenoxy]-3-(6,7-dihydro-5H-
- pyrrolo[1,2-a]imidazol-2-yl)-N-methylbenzene-1-sulfonamide
- 4-17
- 3-(6,7-dihydro-5H-pyrrolo[1,2-a]imidazol-2-yl)-N-methyl-4-{4-
- [(trifluoromethyl)sulfanyl]phenoxy}benzene-1-sulfonamide
- 4-18
- 3-(6,7-dihydro-5H-pyrrolo[1,2-a]imidazol-2-yl)-N-methyl-4-[4-
- (pentafluoro-lambda~6~-sulfanyl)phenoxy]benzene-1-
- sulfonamide
- 4-19
- 3-(6,7-dihydro-5H-pyrrolo[1,2-a]imidazol-2-yl)-4-(2-fluoro-4-
- methylphenoxy)-N-methylbenzene-1-sulfonamide
- 4-20
- 4-(4-chloro-2-fluorophenoxy)-3-(6,7-dihydro-5H-pyrrolo[1,2-
- a]imidazol-2-yl)-N-methylbenzene-1-sulfonamide
- 4-21
- 4-(2,4-difluorophenoxy)-3-(6,7-dihydro-5H-pyrrolo[1,2-a]
- imidazol-2-yl)-N-methylbenzene-1-sulfonamide
- 4-22
- 4-(2,4-difluorophenoxy)-3-(6,7-dihydro-5H-pyrrolo[1,2-a]
- imidazol-2-yl)-N-methylbenzene-1-sulfonamide
- 5-1
- N-(Cyclopropylmethyl)-3-(5,6-dihydro-4H-pyrrolo[1,2-b]
- pyrazol-3-yl)-4-(4-(trifluoromethyl)phenoxy)benzenesulfona-
- mide
- 6-1
- N-Methyl-3-(5-methyl-5,6-dihydropyrrolo[3,4-c]pyrazol-2(4H)-
- yl)-4-(4-(trifluoromethyl)phenoxy)benzenesulfonamide
- 6-2
- 3-(5,6-dihydrocyclopenta[c]pyrazol-2(4H)-yl)-N-methyl-4-[4-
- (trifluoromethyl)phenoxy]benzene-1-sulfonamide
- 7-1
- 3-(6,7-dihydro-5H-pyrrolo[1,2-a]imidazol-2-yl)-N-(propan-2-yl)-
- 4-[4-(trifluoromethyl)phenoxy]benzene-1-sulfonamide
- 7-2
- 3-(6,7-dihydro-5H-pyrrolo[1,2-a]imidazol-2-yl)-N-ethyl-4-[4-
- (trifluoromethyl)phenoxy]benzene-1-sulfonamide
- 7-3
- N-cyclopropyl-3-(6,7-dihydro-5H-pyrrolo[1,2-a]imidazol-2-yl)-
- 4-(4-(trifluoromethyl)phenoxy)benzenesulfonamide
- 8-1
- 4-(4-Chlorophenoxy)-3-(5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-
- 2-yl)-N-methylbenzene-1-sulfonamide
- 8-2
- 3-(5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-2-yl)-4-(4-
- fluorophenoxy)-N-methylbenzene-1-sulfonamide
- 8-3
- 5-(5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-2-yl)-N-methyl-6-[4-
- (trifluoromethyl)phenoxy]pyridine-3-sulfonamide
- 8-4
- 4-[4-(difluoromethyl)phenoxy]-3-(5,6-dihydro-4H-pyrrolo[1,2-
- b]pyrazol-2-yl)-N-methylbenzene-1-sulfonamide
- 9-1
- 3-(7-Hydroxy-6,7-dihydro-5H-pyrrolo[1,2-a]imidazol-2-yl)-N-
- methyl-4-(4-(trifluoromethyl)phenoxy)benzenesulfonamide
- 9-2
- 3-(7-Hydroxy-7-methyl-6,7-dihydro-5H-pyrrolo[1,2-a]imidazol-
- 2-yl)-N-methyl-4-(4-(trifluoromethyl)phenoxy)
- benzenesulfonamide
- 10-1
- 3-(6,7-Dihydro-5H-pyrrolo[1,2-a]imidazol-2-yl)-N-methyl-4-((5-
- (trifluoromethyl)pyridin-2-yl)oxy)benzenesulfonamide
- 11-1
- 5-(6,7-dihydro-5H-pyrrolo[1,2-a]imidazol-2-yl)-N-methyl-6-[4-
- (trifluoromethyl)phenoxy]pyridine-3-sulfonamide
- or a pharmaceutically acceptable salt thereof.
387 more elements
Dependencies are inferred from the claim text.