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US 2024/0082329 A1Published application
Immunogenic combination compositions and uses thereof
AssigneeGlaxosmithkline Biologicals SA
InventorsAndrew GEALL, Ethan SETTEMBRE
Life of this patent
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Abstract
This invention generally relates to immunogenic compositions that comprise an RNA component and a polypeptide component. Immunogenic compositions that deliver antigens in two different forms—a first antigen from a pathogen, in RNA-coded form; and a second antigen from a different pathogen, in polypeptide form—are effective in inducing immune response to both pathogens.
Claims22
An immunogenic composition comprising:
- (i) a first polypeptide antigen that is not associated with a viral replicon particle (VRP), and
- (ii) a self-replicating RNA molecule that encodes a second polypeptide antigen, wherein the self-replicating RNA cannot induce production of infectious viral particles and is provided with a delivery system;
- wherein said first and second antigens are antigens from different pathogens.
An immunogenic composition comprising:
- (i) a Parvovirus polypeptide antigen, and (ii) a self-replicating RNA molecule that encodes a CMV polypeptide antigen.
Dependencies are inferred from the claim text.