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AssigneeUniversity of Florida Research Foundation, Inc.
InventorsLaura Ranum, Monica Banez Coronel
Estimating the term…
Aspects of the disclosure relate to methods and compositions (e.g., kits) for detecting certain repeat-associated non-ATG (RAN) proteins in a subject (e.g., a subject having or suspected of having a disease associated with a CAG and/or CTG repeat expansion). In some embodiments, methods described by the disclosure comprise detecting one or more RAN proteins in a biological sample obtained from a subject by an immunoassay using one or more antibodies that target homopolymeric repeat regions of RAN proteins. In some embodiments, the disclosure relates to kits comprising one or more antibodies that target homopolymeric repeat regions of RAN proteins, and an immunoassay plate and/or reagents. In some embodiments, the disclosure provides methods of producing anti-RAN protein antibodies.
A method for detecting one or more RAN proteins in a subject, the method comprising:
A method for measuring pharmacokinetic changes in RAN protein levels in a subject, the method comprising:
A kit comprising:
A method of producing an antibody, the method comprising administering to a cell or a subject a peptide antigen comprising the sequence set forth in any one of SEQ ID NOs:
Dependencies are inferred from the claim text.