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US 2024/0067925 A1Published application
Skin tissue
AssigneeUniversity of Durham
InventorsMartin GOLDBERG, Iakowos KARAKESISOGLOU, James CARTHEW
Life of this patent
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Abstract
A method of creating skin tissue is described, particularly, an in vitro or ex vivo method for creating skin tissue. The invention extends to the use of agents that disrupt the LINC complex in a skin cell to create the skin tissue, and to using the created tissue in an assay to identify or screen anti-ageing compounds. The invention further extends to model skin tissues per se, uses thereof and to kits for creating such model skin tissues.
Claims20
A method of identifying a skin-softening compound, the method comprising:
- 1. contacting, in the presence of a test compound, a SUN domain with a KASH domain;
- and
- 2. detecting binding between the SUN domain and the KASH domain, wherein an alteration in binding as compared to a control is an indicator that the test compound is a candidate skin-softening compound that disrupts a LINC complex comprising a SUN domain and a KASH domain.
Dependencies are inferred from the claim text.