High anticoagulation ecmo and extracorporeal circulation consumable

A high anticoagulation ECMO and extracorporeal circulation consumable, comprising the following preparation methods:

• S1, aminating the surface of ECMO blood circulation device and extracorporeal circulation consumables:
• adding raw materials rich in amino functional groups into organic solvent, fully stirring and mixing, pouring into the ECMO blood circulation device and extracorporeal circulation consumables, refluxing at 20-80° C. for 2-10 hours, grafting the raw materials rich in amino functional groups onto the inner wall contacting with blood, so that a large amount of amino groups are loaded on the surface, and washing to obtain amino-modified ECMO blood circulation device and extracorporeal circulation consumables;
• S2, activating heparin groups:
• activating heparin groups by direct coupling method, dissolving heparin sodium in MES buffer, adding EDC and NHS, and stirring the solution in ice-water bath for 1 h-5 h to activate active groups of the heparin and generate heparin containing active carboxyl groups;
• S3, heparinizing the ECMO blood circulation device and extracorporeal circulation consumables:
• adding heparin-activated mixed solution into the amino-modified ECMO blood circulation device and extracorporeal circulation consumables, refluxing for 1-20 hours, discharging the solution, repeating this step for 1-3 times, washing with a mixed solution of ethanol and distilled water to obtain heparinized ECMO blood circulation device and extracorporeal circulation consumables, and drying for later use;
• S4, modification of enhancer:
• after the heparinization of the ECMO blood circulation device and extracorporeal circulation consumables is completed, using albumin, functionalized PEG which can react with amino groups, and phosphate to further surface modify the heparinized ECMO blood circulation device and extracorporeal circulation consumables to block the sites not modified by heparinization, so as to shield the adsorption of platelets and protein in blood on the inner wall.