Immunogenic probiotic compositions and methods of use including in vaccination
AssigneeElanco US Inc.
InventorsDharanesh Mahimapura Gangaiah, Arvind Kumar, Nallakannu Pillay Lakshmanan, Shrinivasrao Mane
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Abstract
The present invention provides probiotic compositions and methods for improving animal health, particularly improving and enhancing vaccine response. The probiotic compositions include one or more isolated strains of Lactobacillus species bacteria which colonizes the gastrointestinal tract to increase the health and enhance the immune system and immune response of an animal.
Claims54
A method of stimulating an immune response or increasing antibody titer to a vaccine in a subject, said method comprising:
- administering
- an effective amount of an immunogenic probiotic composition comprising at least one Lactobacillus reuteri strain and wherein the at least one Lactobacillus reuteri strain comprises at least one sequence selected from SEQ ID NO:
- 1-55 and sequences having at least 98%, at least 98.5%, at least 99%, or at least 99.5% sequence identity with at least one of SEQ ID NO:
- 1-55, and
- an infectious respiratory disease vaccine to a subject.
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A method of vaccinating a subject for an infectious respiratory disease or decreasing viral load of an infectious respiratory disease virus in a subject, said method comprising administering
- an effective amount of an immunogenic probiotic composition comprising at least one Lactobacillus reuteri strain and wherein the at least one Lactobacillus reuteri strain comprises at least one sequence selected from SEQ ID NO:1-55 and sequences having at least 98%, at least 98.5%, at least 99%, or at least 99.5% sequence identity with at least one of SEQ ID NO:1-55, and
- an infectious respiratory disease vaccine to a subject.
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An immunogenic probiotic composition, said composition comprising:
- at least one Lactobacillus reuteri strain and wherein the at least one Lactobacillus reuteri strain comprises at least one sequence selected from SEQ ID NO:1-55 and sequences having at least 98%, at least 98.5%,
- at least 99%, or at least 99.5% sequence identity with at least one of SEQ ID NO:1-55,
- a pharmaceutically acceptable carrier, and an infectious respiratory disease vaccine.
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Dependencies are inferred from the claim text.