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AssigneesEdigene (Guangzhou) Inc., Edigene Inc.
InventorsRiguo FANG, Zhongyu SHI, Huihui YANG, Pengfei YUAN
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A culture medium composition for expanding hematopoietic stem cells (HSCs) and maintaining self-renewal capacity and differentiation potential of HSCs, a cell population and an application thereof. The culture medium composition comprises a hematopoietic stem cell medium and a small molecule inhibitor of a PDGFR target. The inhibitor of PDGFR can significantly expand HSCs during in-vitro culture, maintaining a high proportion of HSCs with self-renewal capacity, achieving in-vitro expansion of HSCs while maintaining a relatively high proportion of cells with sternness.
A culture medium composition for expanding hematopoietic stem cells (HSCs) and maintaining self-renewal ability and differentiation potential of HSCs, comprising a hematopoietic stem cell medium and a small molecule inhibitor of a PDGFR target.
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A method for promoting the expansion of HSCs and maintaining the self-renewal capacity of the HSCs, comprising in vitro culturing the HSCs in a culture medium composition containing a small molecule inhibitor of a PDGFR target.
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An HSCs infusion solution, wherein the cell number of CD34+ phenotype HSCs accounts for 40-85% of the total cells.
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