Recombinant Miropin
AssigneesUniversity of Louisville, Jagiellonian University
InventorsJan S. Potempa, Miroslaw Ksiazek, Danuta M. Mizgalska, Malgorzata L. Benedyk-Machaczka
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Abstract
Disclosed herein are recombinant miropin polypeptides capable of inhibiting a broad spectrum of proteases, including Kgp and Rgp gingipains, trypsin, plasmin, elastase, cathepsin G, cathepsin L, and plasma kallikrein. Also disclosed herein are methods of treating a disease or condition in a subject that involves administering to the subject a recombinant miropin disclosed herein.
Claims21
A recombinant miropin polypeptide, comprising the amino acid sequence TAVEMX1X2X3SS (SEQ ID NO:11), wherein if X1 is Val, X2 is not Lys and/or X3 is not Thr, and wherein if X2 is Lys, X1 is not Val and/or X3 is not Thr, and wherein if X3 is Thr, X1 is not Val and/or X2 is not Lys, inhibits different proteases than wildtype miropin
(canceled)
Dependencies are inferred from the claim text.