Methods and compositions for consistent intracoronary administration of a biologic

A system for providing consistent intracoronary administration of a biologic to a plurality of subjects having diverse coronary anatomies using multiple types of guide catheters and a single type of biologic-compatible infusion catheter, the system comprising:

• (a) a first guide catheter having proximal and distal ends, wherein the first guide catheter is adapted for the coronary anatomy of a first subject selected from a plurality of subjects comprising diverse coronary anatomies;
• and
• (b) a plurality of kits, each kit comprising:
• (i) a container comprising the biologic, and
• (ii) an infusion catheter having proximal and distal ends, wherein the infusion catheter is for use in the intracoronary administration of the biologic to a subject, wherein a contact surface of the infusion catheter comprises a material compatible with the biologic, wherein the infusion catheter and biologic in each kit of the plurality of kits are materially identical, and wherein during administration of the biologic to the first subject:
• the distal end of the first guide catheter is capable of being inserted into a coronary artery or vein of the first subject, and
• the infusion catheter is capable of being advanced longitudinally within the lumen of the first guide catheter such that the distal end of the infusion catheter is flush with or extends beyond the distal end of the first guide catheter.