Peri-orbital fullness assessment scale and methods of use thereof

A method of treating peri-orbital fullness in a subject, the method comprising:

• (a) determining if the subject exhibits:
• i. pseudoherniation of one or more upper eyelid fat pads and/or one or more lower eyelid fat pads,
• ii. one or more conditions selected from the group consisting of:
• edema of the fat pad, edema along the soft tissue of the upper and/or lower eyelids, malar mounds due to edema, malar edema, and mild festoons aggravated by edema,
• iii. hypertrophy of an orbicularis oculi muscle along lower eyelid, and
• iv. presence of moderate to severe festoons and/or malar mounds secondary to fat deposition or descent/hypertrophy of the orbicularis oculi muscle;
• and
• (b) scoring an eye of the subject according to the determining step (a);
• and
• (c) treating the subject based on the scoring step (b) using one or more of:
• i. administering a composition that comprises a protein having hyaluronidase and/or 4-methylumbelliferone (4-MU) activity to the peri-orbital region of the subject,
• ii. surgically removing and/or correcting one or more areas of the peri-orbital region of the subject, and
• iii. administering a neuromodulator to the orbicularis oculi muscle of the subject.