Engineered Microorganisms for Producing Substituted Tryptamines
AssigneeAlgae-C Inc.
InventorsFatima Awwad, William Mather Almon Carscallen, Elisa Ines Fantino
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Abstract
Provided herein are microorganisms for producing substituted tryptamines and cell cultures thereof, the microorganisms comprising at least one exogenous nucleic acid molecule that encodes at least one substituted tryptamine biosynthetic pathway enzyme.
Claims20
A microalga or stramenopile comprising at least one exogenous nucleic acid molecule that encodes at least one substituted tryptamine biosynthetic pathway enzyme, wherein the microalga or stramenopile does not comprise an exogenous nucleic acid molecule encoding tryptophan decarboxylase.
A microorganism comprising at least one exogenous nucleic acid molecule that encodes at least one substituted tryptamine biosynthetic pathway enzyme, wherein the at least one substituted tryptamine biosynthetic pathway enzyme comprises a tryptophan decarboxylase, an indole-ethylamine methyltransferase, a tryptamine 4-monooxygenase, and a 4-hydroxytryptamine kinase.
A cell culture comprising (i) a microalga or stramenopile comprising at least one exogenous nucleic acid molecule that encodes at least one substituted tryptamine biosynthetic pathway enzyme and (ii) a culture media supplemented with a high concentration of tryptamine.
Dependencies are inferred from the claim text.