Anti-PD-1 Antibodies and Fusion Proteins

An anti-PD-1 antibody, or an antigen-binding fragment thereof, wherein:

• a. the sequences of CDR1H, CDR2H and CDR3H comprise SEQ ID NOS:
• 21, 22, and 23;
• and
• b. the sequences of CDR1L, CDR2L and CDR3L comprise:
• i. SEQ ID NOS:
• 96, 97 and 82
• ii. SEQ ID NOS:
• 45, 46, and 47;
• iii. SEQ ID NOS:
• 66, 67, and 68;
• iv. SEQ ID NOS:
• 70, 67, and 71;
• v. SEQ ID NOS:
• 73, 74, and 75;
• vi. SEQ ID NOS:
• 77, 78, and 47;
• vii. SEQ ID NOS:
• 80, 81, and 82;
• viii. SEQ ID NOS:
• 77, 78, and 84;
• ix. SEQ ID NOS:
• 77, 86, and 47;
• x. SEQ ID NOS:
• 88, 89, and 47;
• xi. SEQ ID NOS:
• 66, 67, and 47;
• xii. SEQ ID NOS:
• 80, 92, and 75;
• xiii. SEQ ID NOS:
• 80, 94, and 71;
• xiv. SEQ ID NOS:
• 99, 100, and 47;
• xv. SEQ ID NOS:
• 102, 103, and 104;
• xvi. SEQ ID NOS:
• 106, 103, and 47;
• xvii. SEQ ID NOS:
• 108, 103, and 47;
• xviii. SEQ ID NOS:
• 110, 111, and 75;
• xix. SEQ ID NOS:
• 77, 103, and 113;
• xx. SEQ ID NOS:
• 77, 111, and 47;
• xxi. SEQ ID NOS:
• 116, 67, and 47;
• xxii. SEQ ID NOS:
• 118, 119, and 47;
• xxiii. SEQ ID NOS:
• 80, 78, and 47;
• xxiv. SEQ ID NOS:
• 122, 103 and 47;
• xxv. SEQ ID NOS:
• 124, 125, and 75;
• xxvi. SEQ ID NOS:
• 127, 38, and 68;
• xxvii. SEQ ID NOS:
• 129, 130, and 47;
• or
• xxviii. SEQ ID NOS:
• 132, 133, and 75.

An anti-PD-1 antibody, or an antigen-binding fragment thereof, wherein:

• a. the sequences of CDR1H, CDR2H and CDR3H comprise SEQ ID NOS:
• 17, 18, and 19;
• and
• b. the sequences of CDR1L, CDR2L and CDR3L comprise:
• i. SEQ ID NOS:
• 41, 49, and 50;
• ii. SEQ ID NOS:
• 41, 42, and 43;
• iii. SEQ ID NOS:
• 41, 52, and 53;
• iv. SEQ ID NOS:
• 41, 55, and 56;
• or
• v. SEQ ID NOS:
• 58, 59, and 60.

A fusion protein comprising a light chain sequence comprising SEQ ID NO:

• 219 or SEQ ID NO:
• 98 and a first heavy chain sequence comprising SEQ ID NO:
• 240 and a second heavy chain sequence comprising SEQ ID NO:
• 241.