Back to results
US 2023/0416345 A1Published application
New type ii collagen binding proteins
AssigneeNavigo Proteins GmbH
InventorsEva Bosse-Doenecke, Manja Gloser-Braeunig, Jonathan Lotze, Hanna Bobolowski, Erik Fiedler
Life of this patent
Estimating the term…
Abstract
The present invention relates to new type II collagen alpha I chain specific binding proteins. The invention further refers to type II collagen binding proteins further fused to or conjugated to a therapeutically or diagnostically active component. Further aspects of the invention cover the use of these type II collagen binding proteins in medicine.
Claims15
A type II collagen binding protein comprising an amino acid sequence with at least 80% sequence identity to any one of SEQ ID NOs:
- 2, 10, 11, 12, 14, and 15, wherein the type II collagen protein has
- (i) a glutamine (Q) at the position corresponding to position 25 in any of SEQ ID NOs:
- 2, 10, 11, 12, 14 and 15;
- (ii) a tyrosine (Y) at the position corresponding to position 29 in any of SEQ ID NOs:
- 2, 10, 11, 12, 14 and 15;
- and
- (iii) a tryptophan (W) at the position corresponding to position 33 in any of SEQ ID NOs:
- 2, 10, 11, 12, 14 and 15;
- and wherein the type II collagen binding protein has a binding affinity (KD) of less than 10 μM for type II collagen.
6 more elements
8-9. (canceled)
Dependencies are inferred from the claim text.