Prion-fc region fusion protein and use thereof
AssigneeToolgen Incorporated
InventorsSang Woo HAM, Jae Young LEE
Life of this patent
Estimating the term…
Abstract
The present invention relates to prion-Fc region fusion proteins and vectors capable of expressing the prion-Fc region fusion proteins. More particularly, the prion-Fc region fusion protein is a fusion protein comprising the Fc region of a human prion protein and an immunoglobulin. The prion-Fc region fusion protein can function to act on and remove the neurotoxic protein aggregates described above. In addition, the present invention relates to a use the prion-Fc region fusion proteins, or vectors capable of expressing the same, and a method for treating diseases associated with neurotoxic protein aggregates.
Claims21
A fusion protein capable of inducing the removal of neurotoxic protein aggregates, represented by [Formula 1]:
- hPrP−L1−Fc [Formula 1]
- wherein the hPrP is selected from a group of full-length human prion protein, human prion protein fragments, human prion protein variants, and fragment of a human prion protein variants,
- wherein the L1 is a linker or absent,
- wherein the Fc is the Fc region of human or mouse immunoglobulin G, and
- wherein the neurotoxic protein aggregates are one or more selected from a group of alpha-synuclein aggregates, amyloid beta aggregates, tau aggregates, TDP-43 aggregates, and prion aggregates.
-17. (canceled)
-25. (canceled)
Dependencies are inferred from the claim text.