US 2023/0416309 A1 · FUSION PROTEIN AND APPLICATION THEREOF

Fusion protein and application thereof

AssigneesJiangsu Provincial Center for Disease Control and Prevention (Public Health Research Institute of Ji, Jiangsu Recbio Technology Co., Ltd., Beijing Abzymo Biosciences Co., Ltd.

InventorsFengcai ZHU, Jiaping YU, Wenrong YAO, Chuxiao YUAN, Shuang WU, Yanyan ZHANG, Yingsong HU, Xiling GUO, Ling ZHANG, Li XIA, Li ZHANG, Jingxin LI, Hongxing PAN, Jianping CHEN, Yong LIU

Life of this patent

Estimating the term…

Abstract

The present application relates to one or more fusion proteins, comprising a structural domain of SARS-CoV-2 S(Spike) protein. The present application also relates to an immunogenic composition comprising the fusion protein and an application thereof.

Claims45

Dependent claims

A fusion protein comprising:

the receptor-binding domain (RBD) of the SARS-CoV-2 spike protein (S protein) or functionally active fragment thereof, and
the N-terminal domain (NTD) of the SARS-CoV-2 spike protein (S protein) or functionally active fragment thereof, wherein said RBD or functionally active fragment thereof is directly or indirectly linked to said NTD or functionally active fragment thereof.

Dependencies are inferred from the claim text.