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US 2023/0416257 A1Published application
Toll-like receptor agonist
OwnerHelene Bazin-Leeinventor
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Abstract
The present disclosure provides compounds of formula (I), (Ia), and (Ib), squaryl group- containing toll-like receptor ligands Also provided are pharmaceutical compositions and vaccine composition thereof and methods of treating a disease of disorder with the compounds and composition described herein.
Claims36
A compound of Formula (I),
- or a pharmaceutically acceptable salt thereof, wherein,
- n is an integer from 2 to 6;
- Y is
- R1 is hydrogen, C1-C6 alkyl, C1-C6 alkylamino, or C1-C6 alkoxy;
- R2 is C1-C8 alkyl;
- L is a bond or
- m is an integer from 1 to 6;
- X is CH or N;
- Het is a four-, five-, or six-membered saturated heterocycle;
- Z is
- R3 is C6-C20 alkyl, C6-C20 alkenyl, or C(O)R5;
- R4 is hydrogen, C6-C20 alkyl, C6-C20 alkenyl, or C(O)R5;
- R5 C6-C20 alkyl or C6-C20 alkenyl;
- R6 is (C2-C6 alkylene-O)p or a bond;
- and
- p is 0, 1, 2, 3, 4, 5, 6, 7, 8, 9, 10 ,11, 12, 13, 14, 15, 16, 17, 18, 19 or 20,
- wherein
- is the point of attachment to formula (I).
15 more elements
A compound selected from the group consisting of:
- or a pharmaceutically acceptable salt thereof.
Dependencies are inferred from the claim text.