Inhibitors of amino acid transport

A compound of formula I:

• wherein:
• A is selected from:
• R1a is selected from —H and —(C1-C6)alkyl;
• R1b is selected from —H, —OH, —CON(H)2, and —NHC(═O)(H);
• R1c is —(CH2)pOH—;
• L1 is selected from —(CHR2)nOR3—, —R3O(CHR2)n—, —(CH2)mN(R4)R3—, and —R3(R4)N(CH2)m—;
• m is selected independently in each instance from 0 and 1;
• n is selected from 0, 1, and 2;
• p is selected from 0, 1, 2, and 3;
• R2 is selected independently in each instance from —H, —(CH2)mOH, and —CH3;
• R3 is selected from —C(═O)— and —CH2—;
• R4 is selected independently in each instance from —H and —(C1-C6)alkyl;
• L2 is selected from a direct bond, —C(═O)—, —CH(OH)—, —NH(C═O)—, —(C═O)NH—, and —(CH2)mO—(CH2)m—, or is absent when is absent;
• an aryl or heteroaryl moiety, optionally substituted with one or more substituents R5;
• is an aryl or heteroaryl ring, optionally substituted with one or more substituents R5, or is absent when is a bicyclic or polycyclic moiety;
• and
• R5 is selected independently in each instance from hydrogen, (C1-C6)alkyl, halogen, halo(C1-C6)alkyl, nitro, —OH, (C1-C6)alkoxy, halo(C1-C6)alkoxy, cyano, (C1-C6)alkylthio, halo(C1-C6)alkylthio, and amino;
• with the proviso that both of R1c and L1 are not connected to A by an oxygen or a nitrogen atom;
• and
• with the proviso that the following compounds are excluded: