Multiple viscosity oil-in-water composition useful as an injectable filler and a scaffold for collagen growth

Abstract

A filler composition which is a pharmaceutically acceptable oil-in-water emulsion including 1-80 vol. % of a first silicone oil having a first viscosity; 15-98 vol. % of water, 1-3 wt. % of a transport medium; 0.05-10 vol. % of a surfactant; and optionally a second silicone oil having a second viscosity lower than the first. The second silicone oil is provided at 1-80 vol. % when the first viscosity is 30,000 cSt or less, or 0-80 vol. % when the first viscosity is greater than 30,000 cSt. At least one of the first silicone oil and the second silicone oil is dispersed in water as droplets having an average diameter of less than 30 microns. The transport medium is sufficiently biodegradable when implanted intradermally or subcutaneously in a human to provide a temporary scaffold for collagen growth between the droplets. A method of making the filler composition and a soft tissue augmentation method are also disclosed.

Dependencies are inferred from the claim text.