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US 2023/0414759 A1Published application
Novel cyclic peptides based on nanobiostructural control, peptidesomes with core/shell structure comprising same, and uses thereof
AssigneeUIF (University Industry Fpimdatopm), Yonsei University
InventorsYong-Beom LIM, Hyoseok Kim
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Abstract
The present disclosure relates to a novel cyclic peptide based on nano-biostructural control, a peptidesome with a core/shell structure including the same, and a use thereof. The cyclic peptide of the present disclosure may be prepared into a peptidesome having a vesicular structure consisting of a hollow core and a bilayer shell through self-assembly in a liquid. Since the prepared peptidesome is stable not only in vitro but also in vivo, especially against proteases in vivo, it can be usefully used as a drug carrier.
Claims30
A cyclic peptide comprising:
- (a) a hydrophilic peptide consisting of 2 to 12 L- or D-arginine residues;
- and
- (b) a hydrophobic peptide represented by General Formula 1,
- wherein the (a) and the (b) are linked by a linker:
- Xaa1-Lys-Xaa2 [General Formula 1]
- wherein
- each of Xaa1 and Xaa2 is independently tryptophan (W) or phenylalanine (F).
4 more elements
Dependencies are inferred from the claim text.