US 2023/0414724 A1Published application

Treatment of hyperbilirubinemia

AssigneesGenethon, International Centre for Genetic Engineering and Biotechnology

InventorsFEDERICO MINGOZZI, GIUSEPPE RONZITTI, FANNY COLLAUD, ANDRÉS MURO, GIULIA BORTOLUSSI

Life of this patent

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Abstract

The invention relates to a nucleic acid sequence useful in the treatment of hyperbilirubinemia, in particular in the treatment of Crigler-Najjar syndrome. More particularly, the nucleic acid sequence of the present invention is a codon-optimized UGT1A1 coding sequence.

Claims13

Dependent claims

An intron which is a modified intron with decreased open reading frames.

Dependencies are inferred from the claim text.

Facts

Application: 18/339,842Filed 22 Jun 2023
Priority: EP 14305622.425 Apr 2014
Published: 28 Dec 2023
Term ends: Not estimatedThe source records don’t support an estimate.

Classification15 codes

A61K 38/45
Enzymes; Proenzymes; Derivatives thereof: transferases
A61K 48/0058
Characterised by an aspect of the 'active' part of the composition delivered, i.e. the nucleic acid delivered: nucleic acids adapted for tissue…
A61K 48/0066
Characterised by an aspect of the 'active' part of the composition delivered, i.e. the nucleic acid delivered: manipulation of the nucleic acid to…
A61P 1/16
Drugs for disorders of the alimentary tract or the digestive system: for liver or gallbladder disorders, e.g. hepatoprotective agents,…

Family

Application15/303,834Continuation · filed 13 Oct 2016
Application16/553,235Continuation · filed 28 Aug 2019
Application18/339,842Continuation
US 10,471,132 B2Related patent
US 2017/0028036 A1Published application
US 2019/0374619 A1Published application
US 2023/0414724 A1This patent

From the US filing history. Foreign family members aren’t listed.

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