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US 2023/0414592 A1Published application
Non-aqueous liquid nimodipine compositions
AssigneeAzurity Pharmaceuticals, Inc.
InventorHugh Greg THOMAS
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Abstract
Non-aqueous liquid compositions comprising nimodipine having improved stability over aqueous compositions comprising nimodipine are provided herein. Methods of improving neurological outcome by reducing the incidence and severity of ischemic deficits in patients with subarachnoid hemorrhage from ruptured intracranial berry aneurysms with the non-aqueous liquid compositions of the present invention are also detailed herein.
Claims14
A liquid composition, comprising
- (a) nimodipine as the only active ingredient, wherein the nimodipine is present in the liquid composition at a concentration of about 6 mg/mL;
- (b) polyethylene glycol, wherein the polyethylene glycol is present in the liquid composition in an amount of about 50% to about 75% (w/v);
- (c) glycerin, wherein the glycerin is present in the liquid composition in an amount of about 25% to about 60% (w/v);
- wherein about 5% or less nimodipine degradation is observed over a period of at least six months when exposed to 40° C. and 75% relative humidity, and
- wherein the liquid composition is formulated for enteral administration.
2 more elements
Dependencies are inferred from the claim text.