Sustained-release formulations of colchicine and methods of using same
AssigneeMurray and Poole Enterprises Ltd
InventorSusanne Riel
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Abstract
Pharmaceutical compositions of colchicine for once-a-day oral administration are provided. The formulations comprise a sustained-release component and an optional immediate-release component, the compositions of which can be selectively adjusted, respectively, to release the active ingredient along a pre-determined or desired release profile. Methods of treating or preventing cardiovascular disease and/or inflammatory disease in mammalian subjects comprising the administration of the novel formulations disclosed herein are also provided.
Claims10
A method of treating cardiovascular disease in a subject, which comprises:
- orally administering, once daily to the subject, a sustained release means for delivering colchicine.
A method of treating cardiovascular disease in a subject, which comprises:
- administering to the subject a sustained release means for delivering colchicine, wherein the colchicine sustained release means results in less than about 70% of colchicine being released in vitro within about 2 hours at 37.degree. C.
Dependencies are inferred from the claim text.