Volume-based layer-independent framework for detection of retinal pathology

A computer-based method for detecting retinal pathology, the method comprising:

• obtaining a target scan of a retina via an optical coherence tomography (OCT) system;
• registering the target scan volumetrically;
• comparing voxel-wise the target scan to a standard retina volume to detect one or more deviations, wherein the standard retina volume corresponds to an average of a plurality of depth-normalized scans from healthy subjects;
• and
• detecting one or more retinal pathologies in the based retina on the detected one or more deviations.

One or more non-transitory, computer-readable media (NTCRM) having instructions, stored thereon, that when executed by one or more processors of an optical coherence tomography (OCT) system cause the OCT system to:

• obtain a target scan of a retina;
• compare voxel-wise the target scan to a reference retina volume to detect one or more deviations;
• and
• detect one or more retinal pathologies in the retina based on the one or more deviations.