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AssigneesInstitut National de la Sante et de la Recherche Medicale, Universite De Limoges, Chu De Limoges
InventorsJean-Baptiste WOILLARD, Pierre MARQUET
Estimating the term…
The area under the curve (AUC) of an immunosuppressant is the best exposure marker for following the global exposure to an immunosuppressant in an organ of a subject. However, measuring AUC is complicated in routine care as it requires multiple blood samples during the dosing interval, which can be expensive and clinically impractical. The present invention proposes to use artificial intelligence technique to predict AUC values based on the value of some predictors. Such method conducts to surprisingly accurate results. Notably, the method enables to obtain satisfactory results with only two samples.
A method for assessing the area-under-the-concentration-over-time value at a specific time of an immunosuppressant in blood or plasma of a subject after administration of a dose of the immunosuppressant, the subject being treated by a treatment comprising administrations of the drug, the method being computer-implemented and the method comprising the steps of:
A method for assessing the area-under-the-concentration-over-time value at a specific time of an inhibitor in blood or plasma of a subject after administration of a dose of the inhibitor,
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