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US 2023/0410947 A1Published application
Systems and methods for rapid microbial identification
AssigneeThermo Fisher Scientific Inc.
InventorsPing F. Yip, James Stephenson
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Abstract
Mass Spectrometry has been widely used to identify microbes present in a sample. However, rapid analysis (e.g. 1-5 minutes) of spectral data to identify microbes has proven to be very challenging due to the high level of processing required and complexity associated with identification from a large pool of candidate microbes. Disclosed herein are methods and systems for rapidly identifying microbes present in a sample through the application of conditional likelihoods that certain proteoforms are particularly indicative of a candidate microbe.
Claims15
A method for identifying a microbe species, comprising:
- determining a plurality of proteoform values from spectral information derived from mass spectral analysis of a sample comprising an unknown microbe species;
- for one or more of the proteoform values identifying a likelihood the proteoform corresponds to a particular microbe species, wherein the proteoform value belongs to a subset of informative proteoform values for the candidate microbe species;
- determining a conditional likelihood for a plurality of candidate microbe species using the identified likelihoods for each proteoform;
- identifying the conditional likelihood of the candidate microbe species that is a best match to the unknown microbe species.
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Dependencies are inferred from the claim text.